Travis Biechele
Seminars
Tuesday 9th September 2025
Pre-Targeting with in Vivo Click Chemistry for Next-Gen ADCs & Radiopharmaceutical Therapies (RTPs)
3:40 pm
- Mechanisms of dose-limiting, off-target toxicities associated with ADCs
- Pre-targeting as a solution to overcome off-target toxicities and deliver more payload to the tumor – or all payloads classes
- Using in vivo click chemistry as a reunion technology and how this can be used to improve efficacy by minimizing exposure to the body and maximizing tumor drug considerations
Tuesday 9th September 2025
ADCs x Radioligands: The Use of One Technology to Advance the Other
9:30 am
- Discussing key learnings for both technologies to understand where they can lend value to each other
- Convergence of targeting technologies between ADCs and Radio
- Using linker technology from ADC to improve the rapid uptake and excretion profile of radioligands when separating target ligands from radioligand payloads in the tumor
- Overcoming challenges associated with elimination, how do you get an ADC out of the body?
