Joe nabhan
Seminars
Wednesday 10th September 2025
Increasing Tissue Penetration & Limiting Immunogenicity: Differentiating Through Novel Conjugate Design
1:40 pm
- Targeting proteins expressed in a larger number of cancers versus receptors predominantly expressed in solid tumor subsets
- Increasing tissue penetration propensity to achieve more significant internalization and intracellular exposure to the payload with smaller proteins
- Leveraging reduced screening cycles required to optimize linker chemistry with smaller proteins, and modulatory to conjugate different payload types
